Includes bibliographical references and index.
|Statement||edited by Uwe Lendeckel and Nigel M. Hooper.|
|Series||Proteases in biology and disease|
|Contributions||Lendeckel, Uwe., Hooper, N. M.|
|LC Classifications||RC347 .P77 2005|
|The Physical Object|
|ISBN 10||0387231005, 0387231013|
|LC Control Number||2004061518|
Buy Proteases in the Brain (Proteases in Biology and Disease Book 3): Read Books Reviews - 5/5(1). About this book Introduction The brain is no exception to this, with proteases having emerging roles in synaptic plasticity, memory, neurodegenerative disorders such as Alzheimer’s, Parkinson’s and prion diseases, ischemia and traumatic brain injury, inflammatory and infectious diseases, and tumour progression. "Proteases in the Brain is a timely and useful source of information both for those well versed in the role of proteases in the brain and for those who are beginning to realize the important role of this family of enzymes in brain function and dysfunction."--Jacket. Proteases in the Brain This edition published in by Springer. The Physical Object Format paperback Number of pages ID Numbers Open Library OLM ISBN 10 ISBN 13 Lists containing this Book. Loading Related Books. History Created October 7, ; 1 revision; Download catalog record: RDF.
This book looks at the role of proteases, which are enzymes that digest proteins, and the various roles that proteases play in the development of neurodegenerative diseases such as Alzheimer's disease, ALS, epilepsy, multiple sclerosis, as well as numerous other neuromuscular diseases. Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS. Armao D, Kornfeld M, Estrada EY, Grossetete M, Rosenberg GA, , Neutral proteases and disruption of the blood-brain barrier in rat. Brain Res – CrossRef PubMed Google Scholar. This volume would be an extremely useful addition to the bookshelf of anybody with an active interest in the biochemical and pathological processes that underlie some of the more common neurological diseases. In the past the role of proteolysis in these disorders has been largely neglected because it was assumed that it represented a general non-specific metabolic process.
Expression of DPP-IV and related proteases in normal brain and human astrocytic tumors The data on the expression of DPP-IV, DPP-II, FAP and DPP8 and 9 in the human brain is limited. Using immunohistochemistry, Bernstein et al. detected abundant expression of DPP-IV in the immature central nervous system with much lower expression in adults. We are pleased to present to our readers the Proceedings of the International Symposium "Proteases: Potential Role in Health and Disease" which was held in WUrzburg (FRG) during October , The topics discussed included those dealing with the physi ology and pathophysiology. These proteases degrade extracellular matrix (ECM), which provide structural and functional support to the brain tissue, as shown by the degradation of collagen I and III (major components of collagenous ECM), elastin (elastic fibrils of ECM), plasminogen (involved in proteolytic degradation of ECM), as well as casein and haemoglobin. Enzymes and Brain Function There are at least four nutritional causes of mental problems. These include: protease deficiency (difficulty digesting protein), sugar intolerance – the inability to digest disaccharides (common sugars like sucrose) to simple sugars, hypothyroidism and a junk-food diet laced with sugar.